11th European congress on osteoporosis and osteoarthritis and international liver congress 2011: 46th European association for the study of the liver.
نویسنده
چکیده
Following repair of a low-trauma hip fracture, an annual infusion of zoledronic acid (Zometa, Novartis) 5 mg, initiated within 90 days, significantly increased total hip bone mineral density (BMD) in men. “The new data showed consistently that men respond to this treatment as well as women,” said Dr. Boonen. The Novartis-supported study was a subanalysis of the Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly–Recurrent Fracture Trial (HORIZON–RFT), a double-blind, placebo-controlled trial among 2,127 subjects with a recent low-trauma hip fracture. Investigators randomly assigned 508 men 50 years of age or older to receive either once-yearly intravenous (IV) zoledronic acid 5 mg (n = 248) or placebo (n = 260) within 90 days after surgical hip repair. All patients received daily oral calcium (1,000 to 1, 500 mg) and vitamin D (800 to 1,200 IU). Primary endpoints were changes in total hip BMD and the incidence of new clinical fractures at the 24th month. Dr. Boonen reported that changes in total hip BMD at month 24 were significantly greater with zoledronic acid (3.81%; P = 0.0021) than with placebo. Notably, at month 24, total hip BMD increased with zoledronic acid but decreased with placebo (3.59% vs. –0.22%, respectively). At one and three years, respectively, there were significantly greater increases in total hip BMD among subjects receiving Strontium Ranelate (Protelos) and Bone Formation After 6 and 12 Months: Histomorphometric Analysis
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EASL International Liver Congress 2017.
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عنوان ژورنال:
- P & T : a peer-reviewed journal for formulary management
دوره 36 5 شماره
صفحات -
تاریخ انتشار 2011